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The most common symptoms of B12 deficiency and pernicious anemia are: Chronic fatigue Depression Anxiety Paranoia Aggressive behavior Painful pins and needles or numbness in hands and feet Sore, swollen red tongue Burning mouth sensation Difficulty walking without stumbling Short-term memory loss Difficulty concentrating Brain fog Shortness of breath *Multiple sclerosis and vitamin B12 deficiency-pernicious anemia both cause nerve damage, including painful tingling or numbness in the hands and feet and impaired gait

J., S-Adenosylmethionine Rescues Cognitive Deficits in the rTg4510 Animal Model by Stabilizing Protein Phosphatase 2A and Reducing Phosphorylated Tau

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J Exp Med 190:915922